Anti-Aging Strategies
Anti-aging nutritional supplementation and medicine
Much of anti-aging medicine has been concerned with the use of nutritional supplements to extend lifespan.
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The idea that antioxidant supplements, such as Vitamin C, Vitamin E, lipoic acid and N-acetylcysteine, might extend human life stems from the free radical theory of aging.
Diabetes resembles accelerated aging and is associated with cross-linking of proteins by sugars, more specifically monosaccharides. Some believe that anti-glycating supplements (supplements that reduce the protein cross-linking by monosaccharides), such as carnosine, pyridoxamine, benfotiamin and lysine, might reduce aging.
Hormone replacement therapy – which aims at restoring youthful levels of growth hormone, testosterone, estrogen, progesterone, melatonin, DHEA and thyroid (all of which decline with age) – has also been tried as means of reducing the effects of aging.
Other less popular hormones but which might also be useful are oxytocin, insulin, human chorionic gonadotropin (hCG), erythropoietin (EPO), and others.
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Resveratrol is a sirtuin stimulant proposed to extend life in mammals in a similar manner to that claimed for calorie restriction in simple model organisms such as nematodes.
Although some supplements have been shown to be of benefit against some aging-related disease conditions, or have extended average lifespan, only calorie restriction has been shown to extend maximum lifespan in any species.
Calorie Restriction
Calorie restriction (CR) with adequate nutrition has been shown to extend the maximum lifespan of almost every species on which it has been tested, including rats, yeast, fruit flies, and nematodes. In rodents, a roughly 50% maximum lifespan extension is seen with a roughly 50% restriction of calories from what would be consumed by freely-feeding animals.
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Experiments are in progress with primates to test whether calorie restriction can extend the lifespan of long-lived species. Some people believe that these experiments will be successful, and that the results will similarly hold true for humans. A group called the Calorie Restriction Society was formed with the help of Brian M. Delaney, Lisa Walford, and Roy Walford in the mid-1990s. These people may have the willpower and determination to restrict their caloric intake in the hope of extending their lives, but they are very few in number. They communicate by e-mail and have been flown to Washington University in St. Louis to be studied by Dr. John Holloszy. Calorie restriction is under current study at the UW-Madison and several other universities. It has moved into testing on primates.
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Chemical and genetic interventions in animal models
The evidence for use of growth Hormone is mixed. An early study suggested that supplementation of mice with growth hormone increased average life expectency. Additional animal experiments have suggested that growth hormone may generally act to shorten maximum lifespan; knockout mice lacking the receptor for growth hormone live especially long.
Resveratrol is a substance that has been shown to extend the lifespan of yeast, fruit flies and certain fishes. Experiments in mammals are currently underway. The manner by which resveratrol achieves this effect remains unknown, although it has been conjectured that it is involved in the mechanism that underlies the lifespan enhancing effects of calorie restriction.
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Likewise, the Sir2 class of genes is conjectured to be involved in the calorie restriction mechanism; yeast genetically engineered to overexpress Sir2 live longer.
Large availability of insulin generally leads to shorter lifespan. Mice genetically engineered to lack an insulin receptor in fat tissue live longer. Mice with an overexpression of the Klotho gene, which limits insulin sensitivity, also show an extended lifespan.
(Thanks to Wikipedia for this helpful anti-aging guide.)
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